Nanostructured Ag‐Bioglass Implant Coatings with Antibacterial and Osteogenic Activity

Abstract Bone implant failure due to aseptic loosening and biofilm infections is an increasing healthcare problem. Implants may be coated with nanoparticles avoid bacterial colonization promote osseointegration. However, these nanocoatings often require long, expensive, complex manufacturing routes limited clinical translation potential. Here, a multifunctional nanoparticle coating consisting of silver (Ag) bioglass (BG) investigated overcome current limitations by providing synchronously antibacterial osteogenic effect. Flame spray pyrolysis (FSP) exploited as scalable reproducible process synthesize large quantities deposit them on titanium (Ti) substrates. The deposited show homogeneous morphology biomineralize after soaking in simulated body fluid (SBF), while their adhesion Ti substrates promoted situ flame annealing. Ag + ion release from containing BG samples inhibits Staphylococcus aureus formation up 3 log units, the responses pre‐osteoblastic cells directly grown AgBG similar levels alkaline phosphatase activity, calcium collagen production when compared pure Ti. inexpensively synthesized nanostructured coatings exert high bioactivity response maintaining biocompatibility. insights this study can direct development coatings.